A Brønsted base-promoted diastereoselective dimerization of azlactones

A Brønsted base-promoted diastereoselective dimerization of azlactones

A novel Brønsted base system for the diastereoselective dimerization of azlactones using trichloroacetate salts and acetonitrile has been developed. Desired products were obtained in good yields (60–93%) and with up to >19:1 dr after one hour of reaction. Additionally, the relative stereochemistr...

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Bibliographic Details
Main Authors: Danielle L. J. Pinheiro, Gabriel M. F. Batista, Pedro P. de Castro, Leonã S. Flores, Gustavo F. S. Andrade, Giovanni W. Amarante
Format: Article
Language:English
Published: Beilstein-Institut 2017-12-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
azlactones
dimerization
diasteoreselective synthesis
kinetics
streptopyrrolidine analogue
Online Access:https://doi.org/10.3762/bjoc.13.264

Internet

https://doi.org/10.3762/bjoc.13.264

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