In Vivo-Selected Compensatory Mutations Restore the Fitness Cost of Mosaic penA Alleles That Confer Ceftriaxone Resistance in Neisseria gonorrhoeae

In Vivo-Selected Compensatory Mutations Restore the Fitness Cost of Mosaic penA Alleles That Confer Ceftriaxone Resistance in Neisseria gonorrhoeae

Resistance to ceftriaxone in Neisseria gonorrhoeae is mainly conferred by mosaic penA alleles that encode penicillin-binding protein 2 (PBP2) variants with markedly lower rates of acylation by ceftriaxone. To assess the impact of these mosaic penA alleles on gonococcal fitness, we introduced the mos...

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Bibliographic Details
Main Authors: Leah R. Vincent, Samuel R. Kerr, Yang Tan, Joshua Tomberg, Erica L. Raterman, Julie C. Dunning Hotopp, Magnus Unemo, Robert A. Nicholas, Ann E. Jerse, Michael S. Gilmore
Format: Article
Language:English
Published: American Society for Microbiology 2018-04-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/9/2/e01905-17

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http://mbio.asm.org/cgi/content/full/9/2/e01905-17

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