Identification of Unique mRNA and miRNA Expression Patterns in Bone Marrow Hematopoietic Stem and Progenitor Cells After Trauma in Older Adults

Identification of Unique mRNA and miRNA Expression Patterns in Bone Marrow Hematopoietic Stem and Progenitor Cells After Trauma in Older Adults

Older adults have significantly worse morbidity and mortality after severe trauma than younger cohorts. The competency of the innate immune response decreases with advancing age, especially after an inflammatory insult. Subsequent poor outcomes after trauma are caused in part by dysfunctional leukoc...

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Bibliographic Details
Main Authors: Dijoia B. Darden, Julie A. Stortz, McKenzie K. Hollen, Michael C. Cox, Camille G. Apple, Russell B. Hawkins, Jaimar C. Rincon, Maria-Cecilia Lopez, Zhongkai Wang, Eduardo Navarro, Jennifer E. Hagen, Hari K. Parvataneni, Maigan A. Brusko, Michael Kladde, Rhonda Bacher, Babette A. Brumback, Scott C. Brakenridge, Henry V. Baker, Christopher R. Cogle, Alicia M. Mohr, Philip A. Efron
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
hematopoietic stem and progenitor cell
bone marrow
trauma
age
transcriptome
RNA
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01289/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01289/full

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