CYR61 triggers osteosarcoma metastatic spreading via an IGF1Rβ-dependent EMT-like process
Abstract Background Osteosarcoma is the most prevalent primary bone malignancy in children and young adults. These tumors are highly metastatic, leading to poor outcome. We previously demonstrated that Cysteine-rich protein 61 (CYR61/CCN1) expression level is correlated to osteosarcoma aggressivenes...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-01-01
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Series: | BMC Cancer |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12885-019-5282-4 |