CYR61 triggers osteosarcoma metastatic spreading via an IGF1Rβ-dependent EMT-like process

CYR61 triggers osteosarcoma metastatic spreading via an IGF1Rβ-dependent EMT-like process

Abstract Background Osteosarcoma is the most prevalent primary bone malignancy in children and young adults. These tumors are highly metastatic, leading to poor outcome. We previously demonstrated that Cysteine-rich protein 61 (CYR61/CCN1) expression level is correlated to osteosarcoma aggressivenes...

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Bibliographic Details
Main Authors: Nadia Habel, Bojana Stefanovska, Dimitri Carène, Ana Patiño-Garcia, Fernando Lecanda, Olivia Fromigué
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Cancer
Subjects:
Bone tumor
CCN1
IGF
EMT
MET
Metastasis
Online Access:http://link.springer.com/article/10.1186/s12885-019-5282-4

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