Evaluation of the Effects of Mitragyna speciosa Alkaloid Extract on Cytochrome P450 Enzymes Using a High Throughput Assay

Evaluation of the Effects of Mitragyna speciosa Alkaloid Extract on Cytochrome P450 Enzymes Using a High Throughput Assay

The extract from Mitragyna speciosa has been widely used as an opium substitute, mainly due to its morphine-like pharmacological effects. This study investigated the effects of M. speciosa alkaloid extract (MSE) on human recombinant cytochrome P450 (CYP) enzyme activities using a modified Crespi met...

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Bibliographic Details
Main Authors: Raja Elina Raja Aziddin, Zahurin Mohamed, Umarani Subramaniam, Murali Ramachandra, Zamri Chik, Wai Mun Kong
Format: Article
Language:English
Published: MDPI AG 2011-08-01
Series:Molecules
Subjects:
herb-drug interactions
cytochrome P450 (CYP)
Mitragyna speciosa
in vitro
alkaloids
Online Access:http://www.mdpi.com/1420-3049/16/9/7344/

Internet

http://www.mdpi.com/1420-3049/16/9/7344/

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