Trimethylamine N-Oxide Exacerbates Cardiac Fibrosis via Activating the NLRP3 Inflammasome

Trimethylamine N-Oxide Exacerbates Cardiac Fibrosis via Activating the NLRP3 Inflammasome

Background/Aims: Gut microbiota has been reported to correlate with a higher mortality and worse prognosis of cardiovascular diseases. Trimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite of specific dietary nutrients, which is linked to cardiac fibrosis. Recent reports have sugges...

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Bibliographic Details
Main Authors: Xueling Li, Jin Geng, Jinxuan Zhao, Qianqian Ni, Chenze Zhao, Yaru Zheng, Xiaomin Chen, Lihong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Physiology
Subjects:
cardiac fibrosis
TMAO
NLRP3 inflammasome
cardiac fibroblast
doxorubicin
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00866/full

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https://www.frontiersin.org/article/10.3389/fphys.2019.00866/full

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