Mutation of lysine residues in apolipoprotein B-100 causes defective lipoprotein[a] formation

Mutation of lysine residues in apolipoprotein B-100 causes defective lipoprotein[a] formation

Lipoprotein[a] (Lp[a]) is assembled by a two-step process involving an initial lysine-dependent binding between apolipoprotein B-100 (apoB-100) and apolipoprotein[a] (apo[a]) that facilitates the formation of a disulphide bond between apoB-100Cys4,326 and apo[a]Cys4,057. Previous studies of transgen...

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Bibliographic Details
Main Authors: Catherine Y.Y. Liu, Ric Broadhurst, Santica M. Marcovina, Sally P.A. McCormick
Format: Article
Language:English
Published: Elsevier 2004-01-01
Series:Journal of Lipid Research
Subjects:
apolipoprotein[a]
assembly
coronary heart disease
lysine
site-directed mutagenesis
transgenic mice
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520319210

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http://www.sciencedirect.com/science/article/pii/S0022227520319210

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