Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16

Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16

A series of substituted heteroaromatic piperazine and piperidine derivatives were found through virtual screening based on the structure of human enterovirus 71 capsid protein VP1. The preliminary biological evaluation revealed that compounds 8e and 9e have potent activity against EV71 and Coxsackie...

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Bibliographic Details
Main Authors: Xian Zhang, Hongliang Wang, Yuhuan Li, Ruiyuan Cao, Wu Zhong, Zhibing Zheng, Gang Wang, Junhai Xiao, Song Li
Format: Article
Language:English
Published: MDPI AG 2013-04-01
Series:Molecules
Subjects:
virtual screening
piperazine derivative
piperidine derivatives
anti-EV71 activity
anti-CVA16 activity
Online Access:http://www.mdpi.com/1420-3049/18/5/5059

Internet

http://www.mdpi.com/1420-3049/18/5/5059

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