KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells

KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells

Lipid synthesis is required for cell growth and is subject to pharmacologic regulation. Keratinocyte growth factor (KGF) stimulates proliferation and lipogenesis in H292 cells, a pulmonary epithelial cancer cell line, but the signaling pathways are not known. KGF stimulated the expression of the tra...

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Bibliographic Details
Main Authors: Yongsheng Chang, Jieru Wang, Xiaojun Lu, Douglas P. Thewke, Robert J. Mason
Format: Article
Language:English
Published: Elsevier 2005-12-01
Series:Journal of Lipid Research
Subjects:
H292 cells
lipogenesis
lung cancer
keratinocyte growth factor
phosphatidylinositol 3-kinase
sterol-regulatory element binding protein-1
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520328509

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http://www.sciencedirect.com/science/article/pii/S0022227520328509

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