Drug-1,3,4-Thiadiazole Conjugates as Novel Mixed-Type Inhibitors of Acetylcholinesterase: Synthesis, Molecular Docking, Pharmacokinetics, and ADMET Evaluation

Drug-1,3,4-Thiadiazole Conjugates as Novel Mixed-Type Inhibitors of Acetylcholinesterase: Synthesis, Molecular Docking, Pharmacokinetics, and ADMET Evaluation

A small library of new drug-1,3,4-thiazidazole hybrid compounds (<b>3a</b>&#8315;<b>3i</b>) was synthesized, characterized, and assessed for their acetyl cholinesterase enzyme (AChE) inhibitory and free radical scavenging activities. The newly synthesized derivatives show...

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Bibliographic Details
Main Authors: Rabail Ujan, Aamer Saeed, Pervaiz Ali Channar, Fayaz Ali Larik, Qamar Abbas, Mohamed F. Alajmi, Hesham R. El-Seedi, Mahboob Ali Rind, Mubashir Hassan, Hussain Raza, Sung-Yum Seo
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Molecules
Subjects:
mixed-type AChE inhibitors
ADMET parameters
pharmacokinetics
drug-likeness
synthesis
antioxidant activity
molecular docking
1,3,4-thiadiazole-drug
Online Access:https://www.mdpi.com/1420-3049/24/5/860

Internet

https://www.mdpi.com/1420-3049/24/5/860

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