A Rabbit Model for Testing Helper-Dependent Adenovirus-Mediated Gene Therapy for Vein Graft Atherosclerosis

A Rabbit Model for Testing Helper-Dependent Adenovirus-Mediated Gene Therapy for Vein Graft Atherosclerosis

Coronary artery bypass vein grafts are a mainstay of therapy for human atherosclerosis. Unfortunately, the long-term patency of vein grafts is limited by accelerated atherosclerosis. Gene therapy, directed at the vein graft wall, is a promising approach for preventing vein graft atherosclerosis. Bec...

Full description

Bibliographic Details
Main Authors: Lianxiang Bi, Bradley K. Wacker, Emma Bueren, Ervin Ham, Nagadhara Dronadula, David A. Dichek
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
vein graft atherosclerosis model
helper-dependent adenovirus
delayed transduction
durable transgene expression
macrophage accumulation
lipid accumulation
VCAM-1
ICAM-1
gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050117301031

Internet

http://www.sciencedirect.com/science/article/pii/S2329050117301031

Similar Items