Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network

Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network

Polycomb-mediated gene regulation has been implicated in gliomas. Here the authors integrate transcriptomic and epigenomic analyses to define Polycomb-dependent networks that promote gliomagenesis, and find that the Polycomb-dependent silencing of the transcription factor Zfp423hinders survival.

Bibliographic Details
Main Authors: Elena Signaroldi, Pasquale Laise, Silvia Cristofanon, Arianna Brancaccio, Elisa Reisoli, Sina Atashpaz, Maria Rosa Terreni, Claudio Doglioni, Giancarlo Pruneri, Paolo Malatesta, Giuseppe Testa
Format: Article
Language:English
Published: Nature Publishing Group 2016-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10753

Internet

https://doi.org/10.1038/ncomms10753

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