Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network

Polycomb-mediated gene regulation has been implicated in gliomas. Here the authors integrate transcriptomic and epigenomic analyses to define Polycomb-dependent networks that promote gliomagenesis, and find that the Polycomb-dependent silencing of the transcription factor Zfp423hinders survival.

Bibliographic Details
Main Authors:	Elena Signaroldi, Pasquale Laise, Silvia Cristofanon, Arianna Brancaccio, Elisa Reisoli, Sina Atashpaz, Maria Rosa Terreni, Claudio Doglioni, Giancarlo Pruneri, Paolo Malatesta, Giuseppe Testa
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms10753

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spelling	doaj-082aa49bf9c74fc6ad7c119e84550fec2021-05-11T10:57:03ZengNature Publishing GroupNature Communications2041-17232016-02-017111410.1038/ncomms10753Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation networkElena Signaroldi0Pasquale Laise1Silvia Cristofanon2Arianna Brancaccio3Elisa Reisoli4Sina Atashpaz5Maria Rosa Terreni6Claudio Doglioni7Giancarlo Pruneri8Paolo Malatesta9Giuseppe Testa10Department of Experimental Oncology, European Institute of OncologyDepartment of Experimental Oncology, European Institute of OncologyDepartment of Experimental Oncology, European Institute of OncologyDepartment of Experimental Oncology, European Institute of OncologyTrasferimento Genico, IRCCS-AOU San Martino-ISTDepartment of Experimental Oncology, European Institute of OncologyPathology Department, IRCCS San Raffaele Scientific InstitutePathology Department, IRCCS San Raffaele Scientific InstituteDivision of Pathology and Laboratory Medicine, European Institute of OncologyTrasferimento Genico, IRCCS-AOU San Martino-ISTDepartment of Experimental Oncology, European Institute of OncologyPolycomb-mediated gene regulation has been implicated in gliomas. Here the authors integrate transcriptomic and epigenomic analyses to define Polycomb-dependent networks that promote gliomagenesis, and find that the Polycomb-dependent silencing of the transcription factor Zfp423hinders survival.https://doi.org/10.1038/ncomms10753
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Elena Signaroldi Pasquale Laise Silvia Cristofanon Arianna Brancaccio Elisa Reisoli Sina Atashpaz Maria Rosa Terreni Claudio Doglioni Giancarlo Pruneri Paolo Malatesta Giuseppe Testa
spellingShingle	Elena Signaroldi Pasquale Laise Silvia Cristofanon Arianna Brancaccio Elisa Reisoli Sina Atashpaz Maria Rosa Terreni Claudio Doglioni Giancarlo Pruneri Paolo Malatesta Giuseppe Testa Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network Nature Communications
author_facet	Elena Signaroldi Pasquale Laise Silvia Cristofanon Arianna Brancaccio Elisa Reisoli Sina Atashpaz Maria Rosa Terreni Claudio Doglioni Giancarlo Pruneri Paolo Malatesta Giuseppe Testa
author_sort	Elena Signaroldi
title	Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network
title_short	Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network
title_full	Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network
title_fullStr	Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network
title_full_unstemmed	Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network
title_sort	polycomb dysregulation in gliomagenesis targets a zfp423-dependent differentiation network
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-02-01
description	Polycomb-mediated gene regulation has been implicated in gliomas. Here the authors integrate transcriptomic and epigenomic analyses to define Polycomb-dependent networks that promote gliomagenesis, and find that the Polycomb-dependent silencing of the transcription factor Zfp423hinders survival.
url	https://doi.org/10.1038/ncomms10753
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Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network

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