Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp.

Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp.

2-aminoimidazole (2-AI) compounds inhibit the formation of bacterial biofilms, disperse preformed biofilms, and re-sensitize multidrug resistant bacteria to antibiotics. 2-AIs have previously been shown to interact with bacterial response regulators, but the mechanism of interaction is still unknown...

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Bibliographic Details
Main Authors: Morgan E. Milton, Bradley M. Minrovic, Danni L. Harris, Brian Kang, David Jung, Caleb P. Lewis, Richele J. Thompson, Roberta J. Melander, Daina Zeng, Christian Melander, John Cavanagh
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
biofilms
antibiotic resistance
two-component systems
response regulators
Acinetobacter baumannii
Francisella
Online Access:http://journal.frontiersin.org/article/10.3389/fmolb.2018.00015/full

Internet

http://journal.frontiersin.org/article/10.3389/fmolb.2018.00015/full

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