Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response

The response to hypoxia can significantly impact oncogenic processes. Here, the authors define the early transcriptional response to acute hypoxia and identify HIF1A target genes as part of this acute response, providing a resource for investigating context-dependent roles of HIF1A in the biology of...

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Bibliographic Details
Main Authors: Zdenek Andrysik, Heather Bender, Matthew D. Galbraith, Joaquin M. Espinosa
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21687-2