Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen

Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen

Abstract Background The manipulation of dendritic cells (DCs) for cancer vaccination has not reached its full potential, despite the revolution in cancer immunotherapy. DCs are fundamental for CD8+ T cell activation, which relies on cross-presentation of exogenous antigen on MHC-I and can be fostere...

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Bibliographic Details
Main Authors: Stefanie K. Wculek, Joaquín Amores-Iniesta, Ruth Conde-Garrosa, Sofía C. Khouili, Ignacio Melero, David Sancho
Format: Article
Language:English
Published: BMJ Publishing Group 2019-04-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Conventional dendritic cells
cDC1
Cancer immunotherapy
Vaccination
Cell-associated antigen
Cross-presenting dendritic cells
Online Access:http://link.springer.com/article/10.1186/s40425-019-0565-5

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http://link.springer.com/article/10.1186/s40425-019-0565-5

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