Cleavage-Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies

Cleavage-Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies

Native flexibly linked (NFL) HIV-1 envelope glycoprotein (Env) trimers are cleavage-independent and display a native-like, well-folded conformation that preferentially displays broadly neutralizing determinants. The NFL platform simplifies large-scale production of Env by eliminating the need to co-...

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Bibliographic Details
Main Authors: Shridhar Bale, Alexandra Martiné, Richard Wilson, Anna-Janina Behrens, Valérie Le Fourn, Natalia de Val, Shailendra K. Sharma, Karen Tran, Jonathan L. Torres, Pierre-Alain Girod, Andrew B. Ward, Max Crispin, Richard T. Wyatt
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
HIV-1
immunogenicity
viral fusion proteins
vaccines
recombinant protein expression
adjuvants
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01116/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01116/full

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