Changes in apoptotic factors caspase-3, PARP and Bax/Bcl-2 ratio in the ventral tegmental area after the acquisition and extinction of morphine-induced conditioned place preference in the rat

Changes in apoptotic factors caspase-3, PARP and Bax/Bcl-2 ratio in the ventral tegmental area after the acquisition and extinction of morphine-induced conditioned place preference in the rat

Introduction: Chronic high doses of morphine inhibit cell proliferation and induce cell death. One of the centers in reward pathway is the ventral tegmental area (VTA). Stimulation of opioid receptors in the reward circuit in the brain by morphine could be enabling a factor induce apoptosis in some...

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Bibliographic Details
Main Authors: Yasaman Razavi, Najmeh Katebi, Shabnam Zeighamy Alamdary, Shahrbanoo Oryan, Fariba Khodagholi, Abbas Haghparast
Format: Article
Language:fas
Published: Semnan Univeristy of Medical Sciences 2013-06-01
Series:Majallah-i ̒Ilmī-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Simnān
Subjects:
Apoptosis
Ventral tegmental area
Morphine
Conditioned place preference
Western blot
Rat
Online Access:http://koomeshjournal.ir/browse.php?a_id=1884&sid=1&slc_lang=fa

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