Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma

Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma

For several cancer types, mouse models indicate that metastasis occurs early. Here, the authors show that human melanoma cells disseminate early and illustrate a genetic colonisation signature that evolves in parallel at different sites.

Bibliographic Details
Main Authors: Melanie Werner-Klein, Sebastian Scheitler, Martin Hoffmann, Isabelle Hodak, Klaus Dietz, Petra Lehnert, Veronika Naimer, Bernhard Polzer, Steffi Treitschke, Christian Werno, Aleksandra Markiewicz, Kathrin Weidele, Zbigniew Czyz, Ulrich Hohenleutner, Christian Hafner, Sebastian Haferkamp, Mark Berneburg, Petra Rümmele, Anja Ulmer, Christoph A. Klein
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02674-y

Internet

https://doi.org/10.1038/s41467-017-02674-y

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