Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations

Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations

The coding of sensory inputs at the level of vestibular sensory organs is not well understood. In this study, the authors demonstrate that the formation of striolar/central zones during embryogenesis requires Cytochrome P450 26b1 (Cyp26b1)-mediated degradation of retinoic acid and show that Cyp26b1...

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Bibliographic Details
Main Authors: Kazuya Ono, James Keller, Omar López Ramírez, Antonia González Garrido, Omid A. Zobeiri, Hui Ho Vanessa Chang, Sarath Vijayakumar, Andrianna Ayiotis, Gregg Duester, Charles C. Della Santina, Sherri M. Jones, Kathleen E. Cullen, Ruth Anne Eatock, Doris K. Wu
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13710-4

Internet

https://doi.org/10.1038/s41467-019-13710-4

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