Three different polymorphisms of the DPYD gene associated with severe toxicity following administration of 5-FU: a case report

Three different polymorphisms of the DPYD gene associated with severe toxicity following administration of 5-FU: a case report

Abstract Background Dihydropyrimidine dehydrogenase deficiency secondary to polymorphisms in the DPYD gene can lead to significant toxicity associated with the administration of fluoropyrimidine chemotherapy. Case presentation We report a case of a 59-year-old Lebanese woman with metastatic pancreat...

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Bibliographic Details
Main Authors: Deborah Mukherji, Sarah Abdel Massih, Arafat Tfayli, Mariam Kanso, Walid Faraj
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Medical Case Reports
Subjects:
5-FU toxicity
Compound heterozygous polymorphism
Dihydropyrimidine dehydrogenase (DPD) enzyme
DPYD gene
Online Access:http://link.springer.com/article/10.1186/s13256-019-2013-z

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http://link.springer.com/article/10.1186/s13256-019-2013-z

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