Effects of Mutations on Structure–Function Relationships of Matrix Metalloproteinase-1

Effects of Mutations on Structure–Function Relationships of Matrix Metalloproteinase-1

Matrix metalloproteinase-1 (MMP-1) is one of the most widely studied enzymes involved in collagen degradation. Mutations of specific residues in the MMP-1 hemopexin-like (HPX) domain have been shown to modulate activity of the MMP-1 catalytic (CAT) domain. In order to reveal the structural and confo...

Full description

Bibliographic Details
Main Authors: Warispreet Singh, Gregg B. Fields, Christo Z. Christov, Tatyana G. Karabencheva-Christova
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:International Journal of Molecular Sciences
Subjects:
matrix metalloproteinase-1
conformational flexibility
molecular dynamics simulations
mutations
correlated motions
Online Access:http://www.mdpi.com/1422-0067/17/10/1727

Internet

http://www.mdpi.com/1422-0067/17/10/1727

Similar Items