Daptomycin Resistant Staphylococcus aureus Clinical Strain With Novel Non-synonymous Mutations in the mprF and vraS Genes: A New Insight Into Daptomycin Resistance

Daptomycin Resistant Staphylococcus aureus Clinical Strain With Novel Non-synonymous Mutations in the mprF and vraS Genes: A New Insight Into Daptomycin Resistance

Objectives: Daptomycin (DAP) resistance in Staphylococcus aureus is uncommon but there are increasing reports of the emergence of resistance during DAP therapy. Most clinical DAP-resistant S. aureus isolates investigated carried mutations in the mprF gene. The aim of this study was to identify mutat...

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Bibliographic Details
Main Authors: Artur J. Sabat, Marco Tinelli, Hajo Grundmann, Viktoria Akkerboom, Monica Monaco, Maria Del Grosso, Giulia Errico, Annalisa Pantosti, Alexander W. Friedrich
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Microbiology
Subjects:
whole-genome sequencing
Staphylococcus aureus
daptomycin
SNP analysis
MprF
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02705/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.02705/full

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