Evaluation of a flavonoids library for inhibition of pancreatic α-amylase towards a structure–activity relationship

Evaluation of a flavonoids library for inhibition of pancreatic α-amylase towards a structure–activity relationship

α-Amylase has been considered an important therapeutic target for the management of type 2 diabetes mellitus (T2DM), decreasing postprandial hyperglycaemia (PPHG). In the present work, a panel of 40 structurally related flavonoids was tested, concerning their ability to inhibit α-amylase activity, u...

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Bibliographic Details
Main Authors: Carina Proença, Marisa Freitas, Daniela Ribeiro, Sara M. Tomé, Eduardo F. T. Oliveira, Matilde F. Viegas, Alberto N. Araújo, Maria J. Ramos, Artur M. S. Silva, Pedro A. Fernandes, Eduarda Fernandes
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
α-amylase inhibition
diabetes
docking
flavonoids
in vitro
Online Access:http://dx.doi.org/10.1080/14756366.2018.1558221

Internet

http://dx.doi.org/10.1080/14756366.2018.1558221

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