Automated Learning of Subcellular Variation among Punctate Protein Patterns and a Generative Model of Their Relation to Microtubules.

Characterizing the spatial distribution of proteins directly from microscopy images is a difficult problem with numerous applications in cell biology (e.g. identifying motor-related proteins) and clinical research (e.g. identification of cancer biomarkers). Here we describe the design of a system th...

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Bibliographic Details
Main Authors: Gregory R Johnson, Jieyue Li, Aabid Shariff, Gustavo K Rohde, Robert F Murphy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-12-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4704559?pdf=render