Duffy antigen receptor for chemokines mediates chemokine endocytosis through a macropinocytosis-like process in endothelial cells.

Duffy antigen receptor for chemokines mediates chemokine endocytosis through a macropinocytosis-like process in endothelial cells.

The Duffy antigen receptor for chemokines (DARC) shows high affinity binding to multiple inflammatory CC and CXC chemokines and is expressed by erythrocytes and endothelial cells. Recent evidence suggests that endothelial DARC facilitates chemokine transcytosis to promote neutrophil recruitment. How...

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Bibliographic Details
Main Authors: Yani Zhao, Nilam S Mangalmurti, Zeyu Xiong, Bharat Prakash, Fengli Guo, Donna B Stolz, Janet S Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3246497?pdf=render

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http://europepmc.org/articles/PMC3246497?pdf=render

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