Engineered Cardiac Pacemaker Nodes Created by TBX18 Gene Transfer Overcome Source–Sink Mismatch

Engineered Cardiac Pacemaker Nodes Created by TBX18 Gene Transfer Overcome Source–Sink Mismatch

Abstract Every heartbeat originates from a tiny tissue in the heart called the sinoatrial node (SAN). The SAN harbors only ≈10 000 cardiac pacemaker cells, initiating an electrical impulse that captures the entire heart, consisting of billions of cardiomyocytes for each cardiac contraction. How thes...

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Bibliographic Details
Main Authors: Sandra I. Grijalva, Jin‐mo Gu, Jun Li, Natasha Fernandez, Jinqi Fan, Jung Hoon Sung, Seung Yup Lee, Conner Herndon, Erin M. Buckley, Sung‐Jin Park, Flavio H. Fenton, Hee Cheol Cho
Format: Article
Language:English
Published: Wiley 2019-11-01
Series:Advanced Science
Subjects:
biological pacemakers
cell and tissue engineering
sinoatrial nodes
source–sink mismatch
TBX18
Online Access:https://doi.org/10.1002/advs.201901099

Internet

https://doi.org/10.1002/advs.201901099

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