pVHL mediates K63-linked ubiquitination of nCLU.

pVHL mediates K63-linked ubiquitination of nCLU.

pVHL, product of von Hippel-Lindau (VHL) tumor suppressor gene, functions as the substrate recognition component of an E3-ubiquitin ligase that targets proteins for ubiquitination and proteasomal degradation. Hypoxia-inducible factor α (HIFα) is the well-known substrate of pVHL. Besides HIFα, pVHL a...

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Bibliographic Details
Main Authors: Jing Xue, Dan-Dan Lv, Shi Jiao, Wenting Zhao, Xuebing Li, Heng Sun, Bing Yan, Li Fan, Rong-Gui Hu, Jing Fang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3332038?pdf=render

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http://europepmc.org/articles/PMC3332038?pdf=render

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