A 22-amino-acid peptide regulates tight junctions through occludin and cell apoptosis

Occludin is a structural protein of tight junctions (TJ) in the blood–testis barrier (BTB). A 22-amino-acid peptide (22AA) in the second extracellular loop can reversibly regulate TJ, but its regulatory mechanism is unknown. In this study, a 22AA-induced TJ destruction animal model was constructed t...

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Bibliographic Details
Main Authors: Maoying Zhu, Juan Lu, Jianyun Shen, Lumin Fei, Deyu Chen
Format: Article
Language:English
Published: PeerJ Inc. 2020-11-01
Series:PeerJ
Subjects:
TJ
Online Access:https://peerj.com/articles/10147.pdf