Stromal expression of heat-shock protein 27 is associated with worse clinical outcome in patients with colorectal cancer lung metastases.

Stromal expression of heat-shock protein 27 is associated with worse clinical outcome in patients with colorectal cancer lung metastases.

Pulmonary metastases are common in patients with primary colorectal cancer (CRC). Heat-shock protein 27 (Hsp27) is upregulated in activated fibroblasts during wound healing and systemically elevated in various diseases. Cancer-associated fibroblasts (CAFs) are also thought to play a role as prognost...

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Bibliographic Details
Main Authors: Thomas Schweiger, Christoph Nikolowsky, Patrick Starlinger, Denise Traxler, Matthias Zimmermann, Peter Birner, Balazs Hegedüs, Balazs Dome, Michael Bergmann, Michael Mildner, Walter Klepetko, Konrad Hoetzenecker, Hendrik Jan Ankersmit
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4368667?pdf=render

Internet

http://europepmc.org/articles/PMC4368667?pdf=render

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