Effect of initial seeding density on cell behavior-driven epigenetic memory and preferential lineage differentiation of human iPSCs

Understanding the cellular behavioral mechanisms underlying memory formation and maintenance in human induced pluripotent stem cell (hiPSC) culture provides key strategies for achieving stability and robustness of cell differentiation. Here, we show that changes in cell behavior-driven epigenetic me...

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Bibliographic Details
Main Authors: Mee-Hae Kim, Naruchit Thanuthanakhun, Shun Fujimoto, Masahiro Kino-oka
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Stem Cell Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506121003810