Linking the YTH domain to cancer: the importance of YTH family proteins in epigenetics

Abstract N6-methyladenosine (m6A), the most prevalent and reversible modification of mRNA in mammalian cells, has recently been extensively studied in epigenetic regulation. YTH family proteins, whose YTH domain can recognize and bind m6A-containing RNA, are the main “readers” of m6A modification. Y...

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Bibliographic Details
Main Authors: Rongkai Shi, Shilong Ying, Yadan Li, Liyuan Zhu, Xian Wang, Hongchuan Jin
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03625-8