Strategies for monitoring and combating resistance to combination kinase inhibitors for cancer therapy

Abstract Targeted therapies such as kinase inhibitors and monoclonal antibodies have dramatically altered cancer care in recent decades. Although these targeted therapies have improved patient outcomes in several cancer types, resistance ultimately develops to these agents. One potential strategy pr...

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Bibliographic Details
Main Authors: Leanne G. Ahronian, Ryan B. Corcoran
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Genome Medicine
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13073-017-0431-3