Advanced Glycation End Product Inhibitor Pyridoxamine Attenuates IVD Degeneration in Type 2 Diabetic Rats

Advanced Glycation End Product Inhibitor Pyridoxamine Attenuates IVD Degeneration in Type 2 Diabetic Rats

Type 2 diabetes mellitus (T2DM) is associated with advanced glycation end product (AGE) enrichment and considered a risk factor for intervertebral disc (IVD) degeneration. We hypothesized that systemic AGE inhibition, achieved using pyridoxamine (PM), attenuates IVD degeneration in T2DM rats. To ind...

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Bibliographic Details
Main Authors: Juliane D. Glaeser, Derek Ju, Wafa Tawackoli, Jae H. Yang, Khosrowdad Salehi, Tina Stefanovic, Linda E.A. Kanim, Pablo Avalos, Giselle Kaneda, Stephen Stephan, Melodie F. Metzger, Hyun W. Bae, Dmitriy Sheyn
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
intervertebral disc degeneration
type 2 diabetes mellitus
advanced glycation end products
Online Access:https://www.mdpi.com/1422-0067/21/24/9709

Internet

https://www.mdpi.com/1422-0067/21/24/9709

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