Angiotensin II induces connective tissue growth factor expression in human hepatic stellate cells by a transforming growth factor β-independent mechanism

Angiotensin II induces connective tissue growth factor expression in human hepatic stellate cells by a transforming growth factor β-independent mechanism

Abstract Angiotensin II (Ang II) promotes hepatic fibrosis by increasing extracellular matrix (ECM) synthesis. Connective tissue growth factor (CTGF) plays a crucial role in the pathogenesis of hepatic fibrosis and emerges as downstream of the profibrogenic cytokine transforming growth factor-β (TGF...

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Bibliographic Details
Main Authors: Ao Li, Jingyao Zhang, Xiaoxun Zhang, Jun Wang, Songsong Wang, Xiao Xiao, Rui Wang, Peng Li, Yitao Wang
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-08334-x

Internet

https://doi.org/10.1038/s41598-017-08334-x

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