Disruption of TLR3 signaling due to cleavage of TRIF by the hepatitis A virus protease-polymerase processing intermediate, 3CD.

Disruption of TLR3 signaling due to cleavage of TRIF by the hepatitis A virus protease-polymerase processing intermediate, 3CD.

Toll-like receptor 3 (TLR3) and cytosolic RIG-I-like helicases (RIG-I and MDA5) sense viral RNAs and activate innate immune signaling pathways that induce expression of interferon (IFN) through specific adaptor proteins, TIR domain-containing adaptor inducing interferon-β (TRIF), and mitochondrial a...

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Bibliographic Details
Main Authors: Lin Qu, Zongdi Feng, Daisuke Yamane, Yuqiong Liang, Robert E Lanford, Kui Li, Stanley M Lemon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3169542?pdf=render

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http://europepmc.org/articles/PMC3169542?pdf=render

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