APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer

APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer

Estrogen receptor α (ERα) is the key transcriptional driver in a large proportion of breast cancers. We report that APOBEC3B (A3B) is required for regulation of gene expression by ER and acts by causing C-to-U deamination at ER binding regions. We show that these C-to-U changes lead to the generatio...

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Bibliographic Details
Main Authors: Manikandan Periyasamy, Hetal Patel, Chun-Fui Lai, Van T.M. Nguyen, Ekaterina Nevedomskaya, Alison Harrod, Roslin Russell, Judit Remenyi, Anna Maria Ochocka, Ross S. Thomas, Frances Fuller-Pace, Balázs Győrffy, Carlos Caldas, Naveenan Navaratnam, Jason S. Carroll, Wilbert Zwart, R. Charles Coombes, Luca Magnani, Laki Buluwela, Simak Ali
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715009638

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http://www.sciencedirect.com/science/article/pii/S2211124715009638

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