Quantification and Metabolite Identification of Sulfasalazine in Mouse Brain and Plasma Using Quadrupole-Time-of-Flight Mass Spectrometry

Quantification and Metabolite Identification of Sulfasalazine in Mouse Brain and Plasma Using Quadrupole-Time-of-Flight Mass Spectrometry

Sulfasalazine (SAS), an anti-inflammatory drug with potent cysteine/glutamate antiporter system xc- (SXC) inhibition has recently shown beneficial effects in brain-related diseases. Despite many reports related to central nervous system (CNS) effect of SAS, pharmacokinetics (PK) and metabolite ident...

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Bibliographic Details
Main Authors: Jangmi Choi, Min-Ho Park, Seok-Ho Shin, Jin-Ju Byeon, Byeong ill Lee, Yuri Park, Young G. Shin
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Molecules
Subjects:
CNS
sulfasalazine
brain to plasma ratio
LC-ESI-TOF-MS
Online Access:https://www.mdpi.com/1420-3049/26/4/1179

Internet

https://www.mdpi.com/1420-3049/26/4/1179

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