MicroRNA-122 Mimic Improves Stroke Outcomes and Indirectly Inhibits NOS2 After Middle Cerebral Artery Occlusion in Rats

MicroRNA-122 Mimic Improves Stroke Outcomes and Indirectly Inhibits NOS2 After Middle Cerebral Artery Occlusion in Rats

Aim: Our previous study demonstrated miR-122 mimic decreased NOS2 expression in blood leucocytes and improved stroke outcomes when given immediately after middle cerebral artery occlusion (MCAO) in rats. Since NOS2 is associated with neuro-inflammation in stroke and decreasing NOS2 expression alone...

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Bibliographic Details
Main Authors: Bo Lv, Xiyuan Cheng, Frank R. Sharp, Bradley P. Ander, Da Zhi Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Neuroscience
Subjects:
microRNA-122 (miR-122)
ischemic stroke
brain microvascular endothelial cells (BMVECs)
inducible nitric oxide synthase (NOS2)
3′ untranslated regions (3′UTR)
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00767/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00767/full

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