A role for immune responses against non-CS components in the cross-species protection induced by immunization with irradiated malaria sporozoites.

A role for immune responses against non-CS components in the cross-species protection induced by immunization with irradiated malaria sporozoites.

Immunization with irradiated Plasmodium sporozoites induces sterile immunity in rodents, monkeys and humans. The major surface component of the sporozoite the circumsporozoite protein (CS) long considered as the antigen predominantly responsible for this immunity, thus remains the leading candidate...

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Main Authors: Marjorie Mauduit, Anne Charlotte Grüner, Rita Tewari, Nadya Depinay, Michèle Kayibanda, Jean-Marc Chavatte, Jean-François Franetich, Andrea Crisanti, Dominique Mazier, Georges Snounou, Laurent Rénia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2766644?pdf=render

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http://europepmc.org/articles/PMC2766644?pdf=render

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