Live-cell microscopy reveals small molecule inhibitor effects on MAPK pathway dynamics.

Live-cell microscopy reveals small molecule inhibitor effects on MAPK pathway dynamics.

Oncogenic mutations in the mitogen activated protein kinase (MAPK) pathway are prevalent in human tumors, making this pathway a target of drug development efforts. Recently, ATP-competitive Raf inhibitors were shown to cause MAPK pathway activation via Raf kinase priming in wild-type BRaf cells and...

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Bibliographic Details
Main Authors: Daniel J Anderson, Jenni K Durieux, Kyung Song, Ryan Alvarado, Peter K Jackson, Georgia Hatzivassiliou, Mary J C Ludlam
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3150364?pdf=render

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http://europepmc.org/articles/PMC3150364?pdf=render

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