Hepatic CEACAM1 Overexpression Protects Against Diet-induced Fibrosis and Inflammation in White Adipose Tissue

Hepatic CEACAM1 Overexpression Protects Against Diet-induced Fibrosis and Inflammation in White Adipose Tissue

CEACAM1 promotes insulin extraction, an event that occurs mainly in liver. Phenocopying global Ceacam1 null mice (Cc1–/–), C57/BL6J mice fed a high-fat diet exhibited reduced hepatic CEACAM1 levels and impaired insulin clearance, followed by hyperinsulinemia, insulin resistance and visceral obesity....

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Bibliographic Details
Main Authors: Sumona Ghosh Lester, lucia eRusso, Simona Simon Ghanem, Saja Sadik Khuder, Anthony Michael DeAngelis, Emily L Esakov, Thomas A Bowman, Garrett eHeinrich, Qusai Y Al-Share, Marcia F McInerney, William M Philbrick, Sonia Michael Najjar
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Endocrinology
Subjects:
Fibrosis
Inflammation
Insulin Resistance
steatosis
CEACAM1
Insulin clearance
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00116/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00116/full

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