Down regulation of the TCR complex CD3 ζ-chain on CD3+ T cells: a potential mechanism for helminth mediated immune modulation

Down regulation of the TCR complex CD3 ζ-chain on CD3+ T cells: a potential mechanism for helminth mediated immune modulation

The CD3ζ forms part of the T cell receptor (TCR) where it plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways leading to T cell effector functions. Down regulation of CD3ζ leads to impairment of immune responses including reduced cell prolife...

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Bibliographic Details
Main Authors: Laura Jane Appleby, Norman eNausch, Claire Deirdre Bourke, Francisca eMutapi, Nicholas eMidzi, Takafira eMduluza, Judith eAllen, Francesca eHeard, Louise eErskine
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Immunology
Subjects:
Pathology
Schistosomiasis
human
T cells
helminth
antibody
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00051/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00051/full

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