Roles of Lipid Peroxidation-Derived Electrophiles in Pathogenesis of Colonic Inflammation and Colon Cancer

Roles of Lipid Peroxidation-Derived Electrophiles in Pathogenesis of Colonic Inflammation and Colon Cancer

Redox stress is a common feature of gut disorders such as colonic inflammation (inflammatory bowel disease or IBD) and colorectal cancer (CRC). This leads to increased colonic formation of lipid-derived electrophiles (LDEs) such as 4-hydroxynonenal (4-HNE), malondialdehyde (MDA), trans, trans-2,4-de...

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Bibliographic Details
Main Authors: Lei Lei, Jianan Zhang, Eric A. Decker, Guodong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
inflammatory bowel disease
colonic inflammation
colorectal cancer
oxidative stress
lipid peroxidation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.665591/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.665591/full

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