Distinct TP53 Mutation Types Exhibit Increased Sensitivity to Ferroptosis Independently of Changes in Iron Regulatory Protein Activity

Distinct TP53 Mutation Types Exhibit Increased Sensitivity to Ferroptosis Independently of Changes in Iron Regulatory Protein Activity

The tumor suppressor gene <i>TP53</i> is the most commonly mutated gene in human cancer. In addition to loss of tumor suppressor functions, mutations in <i>TP53</i> promote cancer progression by altering cellular iron acquisition and metabolism. A newly identified role for TP...

Full description

Bibliographic Details
Main Authors: Laurie R. Thompson, Thais G. Oliveira, Evan R. Hermann, Winyoo Chowanadisai, Stephen L. Clarke, McKale R. Montgomery
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
mutant TP53
ferroptosis
iron metabolism
iron regulatory proteins
cancer
Online Access:https://www.mdpi.com/1422-0067/21/18/6751

Internet

https://www.mdpi.com/1422-0067/21/18/6751

Similar Items