Gene Therapy Vector Encoding Neuropeptide Y and Its Receptor Y2 for Future Treatment of Epilepsy: Preclinical Data in Rats

Gene Therapy Vector Encoding Neuropeptide Y and Its Receptor Y2 for Future Treatment of Epilepsy: Preclinical Data in Rats

Gene therapy to treat pharmacoresistant temporal lobe epilepsy in humans is now being developed using an AAV vector (CG01) that encodes the combination of neuropeptide Y and its antiepileptic receptor Y2. With this in mind, the present study aimed to provide important preclinical data on the effects...

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Bibliographic Details
Main Authors: Julia Alicja Szczygieł, Kira Iben Danielsen, Esbjörn Melin, Søren Hofman Rosenkranz, Stanislava Pankratova, Annika Ericsson, Karin Agerman, Merab Kokaia, David Paul Drucker Woldbye
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
NPY
Y2
learning and memory
AAV viral vector
hippocampus
gene therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2020.603409/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2020.603409/full

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