Inhibition of p53 and/or AKT as a new therapeutic approach specifically targeting ALT cancers
Abstract While the majority of all human cancers counteract telomere shortening by expressing telomerase, ~15% of all cancers maintain telomere length by a telomerase-independent mechanism known as alternative lengthening of telomeres (ALT). Here, we show that high load of intrinsic DNA damage is pr...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
SpringerOpen
2019-05-01
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Series: | Protein & Cell |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1007/s13238-019-0634-z |