The cytosolic glyoxalases of Plasmodium falciparum are dispensable during asexual blood-stage development

The cytosolic glyoxalases of Plasmodium falciparum are dispensable during asexual blood-stage development

The enzymes glyoxalase 1 and 2 (Glo1 and Glo2) are found in most eukaryotes and catalyze the glutathione-dependent conversion of 2-oxoaldehydes to 2-hydroxycarboxylic acids. Four glyoxalases are encoded in the genome of the malaria parasite Plasmodium falciparum, the cytosolic enzymes PfGlo1 and Pfc...

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Bibliographic Details
Main Authors: Cletus A. Wezena, Romy Alisch, Alexandra Golzmann, Linda Liedgens, Verena Staudacher, Gabriele Pradel, Marcel Deponte
Format: Article
Language:English
Published: Shared Science Publishers OG 2017-11-01
Series:Microbial Cell
Subjects:
Plasmodium falciparum
malaria
glyoxalase
drug target
CRISPR/Cas9
Online Access:http://microbialcell.com/researcharticles/the-cytosolic-glyoxalases-of-plasmodium-falciparum-are-dispensable-during-asexual-blood-stage-development/

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http://microbialcell.com/researcharticles/the-cytosolic-glyoxalases-of-plasmodium-falciparum-are-dispensable-during-asexual-blood-stage-development/

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