The Role of Human Aldo-Keto Reductases (AKRs) in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH-catechols and PAH o-Quinones

The Role of Human Aldo-Keto Reductases (AKRs) in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH-catechols and PAH o-Quinones

Polycyclic aromatic hydrocarbons (PAH) are ubiquitous environmental pollutants. They are procarcinogens requiring metabolic activation to elicit their deleterious effects. Aldo-keto reductases (AKR) catalyze the oxidation of proximate carcinogenic PAH trans-dihydrodiols to yield electrophilic and re...

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Bibliographic Details
Main Authors: Li eZhang, Yi eJin, Meng eHuang, Trevor M. Penning
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-11-01
Series:Frontiers in Pharmacology
Subjects:
aldo-keto reductases
polycyclic aromatic hydrocarbons
o-quinones
Conjugation reactions
Phase II metabolism
Redox cycling
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00193/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00193/full

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